Minimal impact of adjuvant exemestane or tamoxifen treatment on mammographic breast density in postmenopausal breast cancer patients: A Dutch TEAM trial analysis ...

Background . Mammographic breast density is one of the strongest independent risk factors for developing breast cancer. We examined the effect of exemestane and tamoxifen on breast density in Dutch postmenopausal early breast cancer patients participating in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial. Material and methods . Analogue mammograms of selected TEAM participants before start, and after one and two (and if available after three) years of adjuvant endocrine therapy were collected centrally and reviewed. Study endpoints were change in breast density over time, and cor... Mehr ...

Verfasser: Seynaeve, Caroline
Putter, Hein
Nortier, Johan W. R.
Velde, Cornelis J. H. Van De
Nes, Johanna G. H. Van
Beex, Louk V. A. M.
Sramek, Alexandr
Lardenoije, Susanne
Carpentier, Marjolijn Duijm-De
Rongen, Inge Van
Harmien M. Zonderland
Dokumenttyp: Journal contribution
Erscheinungsdatum: 2015
Verlag/Hrsg.: Taylor & Francis
Schlagwörter: Plant Biology / FOS: Biological sciences / Science Policy / Cancer / Biological Sciences / Biotechnology / Molecular Biology / Cell Biology / Engineering / Biophysics
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-28982364
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dx.doi.org/10.6084/m9.figshare.1625349

Background . Mammographic breast density is one of the strongest independent risk factors for developing breast cancer. We examined the effect of exemestane and tamoxifen on breast density in Dutch postmenopausal early breast cancer patients participating in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial. Material and methods . Analogue mammograms of selected TEAM participants before start, and after one and two (and if available after three) years of adjuvant endocrine therapy were collected centrally and reviewed. Study endpoints were change in breast density over time, and correlations between breast density and locoregional recurrence (LRR), distance recurrence (DR), and contralateral breast cancer (CBC). Results . Mammograms of 378 patients (181 tamoxifen, 197 exemestane) were included in the current per protocol analyses. Baseline breast density was low (breast density score < 50% in 75% of patients) and not different between patients randomised to exemestane or tamoxifen (coefficient ...