ObjectiveTo examine quality of life in internationally adopted children with cleft lip and/or palate (CL/P) versus non-adopted children with CL/P.DesignCross sectional study.SettingMultidisciplinary cleft team of a secondary and tertiary hospital in the Netherlands.MethodsParents of children under the age of 8 treated by the multidisciplinary cleft team of our institutions were asked to fill out a questionnaire containing demographic and clinical data and a validated parent proxy measure of cleft-specific quality of life instrument for children aged 0–8: the CleftChild-8. Adopted children were matched to non-adopted children using propensity score matching based on sex, age, type of cleft, if palatal surgery was completed and the level of education of the parent. CleftChild-8 scores were then compared between the matched samples of adopted and non-adopted children with CL/P.Main Outcome Measure(s)Differences in (sub)domain scores of the CleftChild-8.ResultsMost median CleftChild-8 scores of the adopted ...