Prevalence of the variant allele rs61764370 T>G in the 3′UTR of among Dutch , and non-/ breast cancer families

International audience ; Recently, a variant allele in the 3′UTR of the gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families. This functional variant has been shown to disrupt a - miRNA binding site leading to increased expression of KRAS in vitro. In the current study, we have genotyped this -variant in breast cancer index cases from 268 families, 89 families, 685 non-/ families, and 797 geographically m... Mehr ...