The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) is employed as an intercomparison tool for validating TROPOspheric Monitoring Instrument (TROPOMI) satellite NO 2 retrievals against high-resolution Airborne Prism EXperiment (APEX) remote sensing observations performed in June 2019 in the region of Antwerp, a major hotspot of NO 2 pollution in Europe. The model is first evaluated using meteorological and chemical observations in this area. Sensitivity simulations varying the model planetary layer boundary (PBL) parameterization were conducted for a 3 d period in June 2019, indicating a generally good performance of most parameterizations against meteorological data (namely ceilometer, surface meteorology, and balloon measurements), except for a moderate overestimation ( ∼ 1 m s −1 ) of near-surface wind speed. On average, all but one of the PBL schemes reproduce the surface NO 2 measurements at stations of the Belgian Interregional Environmental Agency fairly well, although surface NO 2 is generally underestimated during the day (between −4.3 % and −25.1 % on average) and overestimated at night (8.2 %–77.3 %). This discrepancy in the diurnal evolution arises despite (1) implementing a detailed representation of the diurnal cycle of emissions (Crippa et al., 2020) and (2) correcting the modeled concentrations to account for measurement interferences due to NO y reservoir species, which increases NO 2 concentrations by about 20 % during the day. The model is further evaluated by comparing a 15 d simulation with surface NO 2 , NO, CO, and O 3 data in the Antwerp region. The modeled daytime NO 2 concentrations are more negatively biased during weekdays than during weekends, indicating a misrepresentation of the weekly temporal profile applied to the emissions obtained from Crippa et al. (2020). Using a mass balance approach, we determined a new weekly profile of NO x emissions, leading to a homogenization of the relative bias among the different weekdays. The ratio of weekend to weekday ...