The session is aimed to take a regional look at tobacco control in Europe in order to better understand cultural, social, economic and political conditions for development of tobacco control policies and programs at this region. In addition, the regional approach for tobacco control helps complete geographical look at tobacco control in European region, raise awareness on best practices in analyzed countries and open the door for stronger collaboration and partnership between them in tobacco control policies and programs. Four countries, representing different parts of Europe and considered as case studies, have been selected for comparative analysis: Belgium, Georgia, Poland and Romania. Three of them reflect the level of tobacco control in Western, Central and Southern part of the European Union, one in non-EU Eastern region of Europe. The session refers to the book under the same title that is now planned to be published by the European Network for Smoking Prevention and is based on the template of the US Surgeon General Report on the Health Consequences of Tobacco Use. The session consists of seven short presentations that present the project’s approach, concept and methodology and summarize results and conclusions of comparative analysis made in particular parts of the book dedicated to exposure to tobacco smoke, its health consequences, public beliefs, opinions and attitudes about smoking, its health effects and tobacco control policies, advances in tobacco control legislation and strategy, smoking prevention, cessation and tobacco control advocacy, and a vision of the future strategy for tobacco control.