Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium.

Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and were associated with liver abscesses. Primary extra-hepatic infections were reported in 36% and sepsis for 95% of the patients with 30% of deaths. Improved clinical and microbiological diagnostics are required as hvKp may represent an underestimate... Mehr ...

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Verfasser: Anantharajah, Ahalieyah
Deltombe, Matthieu
de Barsy, Marie
Evrard, Stéphanie
Denis, Olivier
Bogaerts, Pierre
Hallin, Marie
Miendje Deyi, Véronique Yvette
Pierard, Denis
Bruynseels, Peggy
Boelens, Jerina
Glupczynski, Gerald
Huang, Te-Din
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Verlag/Hrsg.: Springer
Schlagwörter: Capsular serotype / Hypermucoviscosity / Hypervirulence / Klebsiella pneumoniae / Molecular epidemiology / Whole genome sequencing
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28960585
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://hdl.handle.net/2078.1/259980

Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and were associated with liver abscesses. Primary extra-hepatic infections were reported in 36% and sepsis for 95% of the patients with 30% of deaths. Improved clinical and microbiological diagnostics are required as hvKp may represent an underestimated cause of community-acquired invasive infections in Belgium.