Characterization of emerging serotype 19A pneumococcal strains in invasive disease and carriage, Belgium

Abstract: After switching from 13-valent to 10-valent pneumococcal conjugate vaccine (PCV10) (2015-2016) for children in Belgium, we observed rapid reemergence of serotype 19A invasive pneumococcal disease (IPD). Whole-genome sequencing of 166 serotype 19A IPD isolates from children (n = 54) and older adults (n = 56) and carriage isolates from healthy children (n = 56) collected after the vaccine switch (2017-2018) showed 24 sequence types (STs). ST416 (global pneumococcal sequence cluster [GPSC] 4) and ST994 (GPSC146) accounted for 75.9% of IPD strains from children and 65.7% of IPD (children... Mehr ...

Verfasser: Desmet, Stefanie
Theeten, Heidi
Laenen, Lies
Cuypers, Lize
Maes, Piet
Bossuyt, Wouter
van Heirstraeten, Liesbet
Peetermans, Willy E.
Lagrou, Katrien
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Schlagwörter: Human medicine
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28956703
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/10067/1906870151162165141