Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium

Abstract In the field of oncology research, next-generation sequencing has contributed significantly to the discovery of DNA mutations associated with diagnosis and prognosis. It also aids in the development of targeted therapies to specific mutations and the rise of personalized medicine. As part of molecular diagnostics in cancer patients, analysis by next-generation sequencing is becoming part of routine clinical practice. The introduction of this complex technology in a healthcare system comes with multiple challenges and requires a clear action plan. Such an action plan, as outlined in th... Mehr ...

Verfasser: Els Van Valckenborgh
Aline Hébrant
Aline Antoniou
Wannes Van Hoof
Johan Van Bussel
Patrick Pauwels
Roberto Salgado
Waltruda Van Doren
Anouk Waeytens
Marc Van den Bulcke
Dokumenttyp: Artikel
Erscheinungsdatum: 2018
Reihe/Periodikum: Archives of Public Health, Vol 76, Iss 1, Pp 1-7 (2018)
Verlag/Hrsg.: BMC
Schlagwörter: Next-generation sequencing / Health care / Cancer / Personalized medicine / Public aspects of medicine / RA1-1270
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28946202
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://doi.org/10.1186/s13690-018-0295-z

Abstract In the field of oncology research, next-generation sequencing has contributed significantly to the discovery of DNA mutations associated with diagnosis and prognosis. It also aids in the development of targeted therapies to specific mutations and the rise of personalized medicine. As part of molecular diagnostics in cancer patients, analysis by next-generation sequencing is becoming part of routine clinical practice. The introduction of this complex technology in a healthcare system comes with multiple challenges and requires a clear action plan. Such an action plan, as outlined in this paper, was developed in Belgium and includes steps in ensuring the quality and indications of NGS testing, installing data registration and tackling ethical issues. A final step is to perform a pilot study to control the access, quality, harmonization and expertise in DNA testing. This action plan can serve as a guide for similar initiatives by other countries to facilitate NGS implementation in clinical practice.