Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study

Purpose: To describe acute respiratory distress syndrome (ARDS) severity, ventilation management, and the outcomes of ICU patients with laboratory-confirmed COVID-19 and to determine risk factors of 90-day mortality post-ICU admission. Methods: COVID-ICU is a multi-center, prospective cohort study conducted in 138 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, adjunctive interventions, ICU length-of-stay, and survival data were collected. Results: From February 25 to May 4, 2020, 4643 patients (median [IQR] age 63 [54-71] years and SAPS II 37 [28-50]... Mehr ...

Verfasser: COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Schlagwörter: info:eu-repo/classification/ddc/617 / Acute respiratory distress syndrome / COVID-19 / Mechanical ventilation / Mortality risk factor / Outcome / Aged / Belgium / epidemiology / COVID-19 / complications / COVID-19 / mortality / Critical Illness / Female / France / epidemiology / Hospital Mortality / Humans / Intensive Care Units / Kaplan-Meier Estimate / Male / Middle Aged / Patient Acuity / Prospective Studies / Respiration / Artificial / Respiratory Distress Syndrome / etiology / Respiratory Distress Syndrome / mortality / Respiratory Distress Syndrome / therapy / Risk Factors / SARS-CoV-2
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28945561
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://archive-ouverte.unige.ch/unige:161818

Purpose: To describe acute respiratory distress syndrome (ARDS) severity, ventilation management, and the outcomes of ICU patients with laboratory-confirmed COVID-19 and to determine risk factors of 90-day mortality post-ICU admission. Methods: COVID-ICU is a multi-center, prospective cohort study conducted in 138 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, adjunctive interventions, ICU length-of-stay, and survival data were collected. Results: From February 25 to May 4, 2020, 4643 patients (median [IQR] age 63 [54-71] years and SAPS II 37 [28-50]) were admitted in ICU, with day-90 post-ICU admission status available for 4244. On ICU admission, standard oxygen therapy, high-flow oxygen, and non-invasive ventilation were applied to 29%, 19%, and 6% patients, respectively. 2635 (63%) patients were intubated during the first 24 h whereas overall 3376 (80%) received invasive mechanical ventilation (MV) at one point during their ICU stay. Median (IQR) positive end-expiratory and plateau pressures were 12 (10-14) cmH 2 O, and 24 (21-27) cmH 2 O, respectively. The mechanical power transmitted by the MV to the lung was 26.5 (18.6-34.9) J/min. Paralyzing agents and prone position were applied to 88% and 70% of patients intubated at Day-1, respectively. Pulmonary embolism and ventilator-associated pneumonia were diagnosed in 207 (9%) and 1209 (58%) of these patients. On day 90, 1298/4244 (31%) patients had died. Among patients who received invasive or non-invasive ventilation on the day of ICU admission, day-90 mortality increased with the severity of ARDS at ICU admission (30%, 34%, and 50% for mild, moderate, and severe ARDS, respectively) and decreased from 42 to 25% over the study period. Early independent predictors of 90-day mortality were older age, immunosuppression, severe obesity, diabetes, higher renal and cardiovascular SOFA score components, lower PaO 2 /FiO 2 ratio and a shorter time between first symptoms and ICU admission. Conclusion: Among more than 4000 ...