peer reviewed ; Many studies support the hypothesis of a substantial benefit in inducing an Opiate Receptor Blockade through a Rapid Opiate Detoxification under general Anaesthesia (RODA) in opiate dependent patients. However, prospective studies and long term evaluation of the technique are lacking. In order to evaluate long-term abstinence rates after a RODA among a sample of opiate addicts, a study was started in March 1999 at the University of Liège. To date, 45 patients were evaluated (mean age: 29 ± 5 years) with a mean opiate dependence duration of 8 ± 4 years. Most of them were both heroin and methadone dependent; 42.2% of them were included while 31.1% did not complete the whole inclusion procedure and 26.7 % were excluded. None experienced severe withdrawal symptoms. At six months, abstinence rate was 67 % and 46 % at one year. These preliminary results suggest the interest of the procedure in carefully selected patients.