Risks Related To Exposure Of The Belgian Population To Lead ...

Risks for health, bound to lead exposure, were evaluated by EFSA and JECFA in 2010. These two bodies have concluded that the PTWI (Provisional Tolerable Weekly Intake) of 25 μg lead/kg body weight was no longer appropriate for the protection of health. Considering the new information on lead, the Scientific Committee has grasped a dossier to reassess the risks of lead for the Belgian population and to use existing methodologies (approach Margin Of Exposure, MOE) to characterize the risks in absence of PTWI. The EFSA CONTAM Panel identified the developmental neurotoxicity in children, cardiovas... Mehr ...

Verfasser: Federal Agency For The Safety Of The Food Chain
Dokumenttyp: Scholarlyarticle
Erscheinungsdatum: 2010
Verlag/Hrsg.: Zenodo
Schlagwörter: Opinion / lead / benchmark dose lower confidence limit / margin of exposure / population exposure / risk assessment / Belgium / http://id.agrisemantics.org/gacs/C2003 / http://id.agrisemantics.org/gacs/C22911 / http://id.agrisemantics.org/gacs/C1470
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-28884241
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dx.doi.org/10.5281/zenodo.438980

Risks for health, bound to lead exposure, were evaluated by EFSA and JECFA in 2010. These two bodies have concluded that the PTWI (Provisional Tolerable Weekly Intake) of 25 μg lead/kg body weight was no longer appropriate for the protection of health. Considering the new information on lead, the Scientific Committee has grasped a dossier to reassess the risks of lead for the Belgian population and to use existing methodologies (approach Margin Of Exposure, MOE) to characterize the risks in absence of PTWI. The EFSA CONTAM Panel identified the developmental neurotoxicity in children, cardiovascular effects and nephrotoxicity in adults as critical effects for risk assessment and derived Benchmark Dose Lower Confidence Limits (BMDL) values for these critical effects. The lowest BMDL value for lead dietary intake was derived from lead concentration in blood. This is 0,5 μg lead/kg body weight/day for developmental neurotoxicity in children. In the current evaluation, different routes of exposure were considered ... : BE; fr; secretariaat.scicom@favv-afsca.be ...