The COVID-19 pandemic led to sustained surveillance efforts, which made unprecedented volumes and types of data available. In Belgium, these data were used to conduct a targeted and regular assessment of the epidemiological situation. In addition, management tools were developed, incorporating key indicators and thresholds, to define risk levels and offer guidance to policy makers. Categorizing risk into various levels provided a stable framework to monitor the COVID-19 epidemiological situation and allowed for clear communication to authorities. Although translating risk levels into specific public health measures has remained challenging, this experience was foundational for future evaluation of the situation for respiratory infections in general, which, in Belgium, is now based on a management tool combining different data sources. ; Funding The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Funding was provided by the Belgian Federal and Regional Authorities and the National Insurance system (RIZIV-INAMI). Acknowledgments The authors sincerely thank the members of the RAG epidemiology group who provided advice and expertise on a weekly basis for more than 3 years. The authors also thank colleagues from the Epidemiology of Infectious Diseases service of Sciensano, who were involved in data collection, data management, and analysis during the COVID-19 crisis, as well as colleagues from the Crisis Management and Strategy service of Sciensano for input on this manuscript. The authors finally thank all data providers.