Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: A phase II randomized study from the belgian hematological society

Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n = 49) or 8 Gy TLI + anti-thymocyte globulin (TLI-ATG arm; n = 45) conditioning. Results: The 180-day cumulative incidences of grade II-IV acute GVHD... Mehr ...

Verfasser: Baron, Frédéric
Theunissen, Koen
Willems, Evelyne
Emonds, Marie Paule
De Becker, Anne
Beguin, Yves
Zachée, Pierre
Maertens, Johan
Kerre, Tessa
Ory, Aurélie
Seidel, Laurence
Graux, Carlos
Lewalle, Philippe
Van Gelder, Michel
Dokumenttyp: Artikel
Erscheinungsdatum: 2015
Schlagwörter: Cancérologie / Hématologie / Biologie moléculaire / Allo-HCT / ATG / Graft-versus-leukemia effects / GVHD / Non-myeloablative conditioning / TBI / TLI
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28877709
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/205806