Histopathological examination.
A, B Cerebellum: Marked attenuation of all cortical layers and necrotic Purkinje cells (arrowheads) ( A ) compared to control ( B ). ML: molecular layer, PL: Purkinje cell layer, GL: granule cell layer, WM: white matter; HE-staining, bar = 100 μm. C, D Spinal cord white matter: Diminished myelination (blue staining) and axonal degeneration (arrowhead) ( C ) compared to control ( D ); HE-LFB staining, bar = 50 μm. E, F Cerebellum: Increased numbers and activation of astrocytes particularly in Purkinje cell and granule cell layer ( E ) compared to control ( F ); GFAP-IHC, bar = 100 μm. G, H Spin... Mehr ...
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| Dokumenttyp: | Image |
| Erscheinungsdatum: | 2021 |
| Schlagwörter: | Medicine / Genetics / Neuroscience / Developmental Biology / Science Policy / Infectious Diseases / Environmental Sciences not elsewhere classified / Biological Sciences not elsewhere classified / selenium transport / SELENOP gene / CNS atrophy / 735 control genomes / protein coding sequence / genome sequence data / Belgian Shepherd dogs / CNS selenium deficiency / cerebellar ataxia / CACA / Total selenium levels |
| Sprache: | unknown |
| Permalink: | https://search.fid-benelux.de/Record/base-28875029 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://doi.org/10.1371/journal.pgen.1009716.g002 |
A, B Cerebellum: Marked attenuation of all cortical layers and necrotic Purkinje cells (arrowheads) ( A ) compared to control ( B ). ML: molecular layer, PL: Purkinje cell layer, GL: granule cell layer, WM: white matter; HE-staining, bar = 100 μm. C, D Spinal cord white matter: Diminished myelination (blue staining) and axonal degeneration (arrowhead) ( C ) compared to control ( D ); HE-LFB staining, bar = 50 μm. E, F Cerebellum: Increased numbers and activation of astrocytes particularly in Purkinje cell and granule cell layer ( E ) compared to control ( F ); GFAP-IHC, bar = 100 μm. G, H Spinal cord gray matter: Increased numbers and activation of microglia associated with neuronal degeneration (arrowhead) ( G ) compared to control ( H ); Iba1-IHC, bar = 50 μm.