Four decades of stem cell transplantation for Fanconi anaemia in the Netherlands
Summary This article presents the haematopoietic stem cell transplantation ( SCT ) results of the complete Dutch Fanconi anaemia ( FA ) patient cohort. Sixty‐eight Dutch FA patients have been transplanted since 1972. In total, 63 (93%) patients engrafted, 54 after first SCT and 9 after second SCT . Fludarabine (FLU)‐based conditioning was associated with decreased graft failure (odds ratio 0·21, P = 0·01), decreased early mortality (hazard ratio 0·25, P = 0·01) and improved 5‐year overall survival (FLU 87·8% [standard error ( SE ) 5·1%] versus non‐FLU 59·3% [ SE 9·5%], P = 0·01). Late mortalit... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2016 |
Reihe/Periodikum: | British Journal of Haematology ; volume 174, issue 6, page 952-961 ; ISSN 0007-1048 1365-2141 |
Verlag/Hrsg.: |
Wiley
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Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28808600 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1111/bjh.14165 |