Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway

Heart rate variability is an important risk factor for cardiovascular disease and all-causemortality. The acetylcholine pathway plays a key role in explaining heart rate variability in humans. We assessed whether 443 genotyped and imputed common genetic variants in eight key genes (CHAT, SLC18A3, SLC5A7, CHRNB4, CHRNA3, CHRNA, CHRM2 and ACHE) of the acetylcholine pathway were associated with variation in an establishedmeasure of heart rate variability reflecting parasympathetic control of the heart rhythm, the root mean square of successive differences (RMSSD) of normal RR intervals. The assoc... Mehr ...

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Verfasser: Riese, H.
Munoz, L.M.
Hartman, C.A.
Ding, X.
Su, S.
Oldehinkel, A.J.
van Room, A.M.
van der Most, P.J.
Lefrandt, J.
Gansevoort, R.T.
van der Harst, P.
Verweij, N.
Licht, C.M.M.
Boomsma, D.I.
Hottenga, J.J.
Willemsen, G.
Penninx, B.W.J.H.
Nolte, I.M.
de Geus, E.J.C.
Wang, X.
Snieder, H.
Dokumenttyp: Artikel
Erscheinungsdatum: 2014
Reihe/Periodikum: Riese , H , Munoz , L M , Hartman , C A , Ding , X , Su , S , Oldehinkel , A J , van Room , A M , van der Most , P J , Lefrandt , J , Gansevoort , R T , van der Harst , P , Verweij , N , Licht , C M M , Boomsma , D I , Hottenga , J J , Willemsen , G , Penninx , B W J H , Nolte , I M , de Geus , E J C , Wang , X & Snieder , H 2014 , ' Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway ' , PLoS ONE , vol. 9 , no. 11 , e112476 . https://doi.org/10.1371/journal.pone.0112476
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28801655
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/e4dcbb4d-e693-44c0-a804-faf50987fdd6