Background: Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined. Methods: We performed DNA modification analysis in white blood cells from monozygotic twins discordant for MDD, in brain prefrontal cortex, and germline (sperm) samples from affected individuals and control subjects (total N = 304) using 8.1K CpG island microarrays and fine mapping. In addition to the trad... Mehr ...
| Verfasser: |
Oh, G.
Wang, S.C.
Pal, M.
Chen, Z.F.
Khare, T.
Tochigi, M.
Ng, C.
Yang, Y.A.
Kwan, A.
Kaminsky, Z.A.
Mill, Jonathan
Gunasinghe, C.
Tackett, J.L.
Gottesman, I.I.
Willemsen, G.
de Geus, E.J.C.
Vink, J.M.
Slagboom, P.E.
Wray, N.R.
Heath, A.C.
Montgomery, G.W.
Turecki, G.
Martin, N.G.
Boomsma, D.I.
McGuffin, P.
Kustra, R.
Petronis, A. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2015 |
| Reihe/Periodikum: |
Oh , G , Wang , S C , Pal , M , Chen , Z F , Khare , T , Tochigi , M , Ng , C , Yang , Y A , Kwan , A , Kaminsky , Z A , Mill , J , Gunasinghe , C , Tackett , J L , Gottesman , I I , Willemsen , G , de Geus , E J C , Vink , J M , Slagboom , P E , Wray , N R , Heath , A C , Montgomery , G W , Turecki , G , Martin , N G , Boomsma , D I , McGuffin , P , Kustra , R & Petronis , A 2015 , ' DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons ' , Biological Psychiatry , vol. 77 , no. 3 , pp. 246-255 . https://doi.org/10.1016/j.biopsych.2014.06.016 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28801458 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/c273cb13-c3d1-4e6d-b2a3-45a6be4933bb |
