A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in... Mehr ...

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Verfasser: Estrada, K.
Krawczak, M.
Schreiber, S
van Duijn, K.
Stolk, L.
van Meurs, J.B.J.
Liu, F.
Penninx, B.W.J.H.
Smit, J.H.
Vogelzangs, N.
Hottenga, J.J.
Willemsen, G.
de Geus, E.J.C.
Lorentzon, M.
von Eller-Eberstein, H.
Lips, P.T.A.M.
van Schoor, N.M.
Pop, V.
de Keijzer, J.
Hofman, A.
Aulchenko, Y.S.
Oostra, B.A.
Ohlsson, C.
Boomsma, D.I.
Uitterlinden, A.G.
van Duijn, C.M.
Rivadeneira, F.F.
Kayser, M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2009
Reihe/Periodikum: Estrada , K , Krawczak , M , Schreiber , S , van Duijn , K , Stolk , L , van Meurs , J B J , Liu , F , Penninx , B W J H , Smit , J H , Vogelzangs , N , Hottenga , J J , Willemsen , G , de Geus , E J C , Lorentzon , M , von Eller-Eberstein , H , Lips , P T A M , van Schoor , N M , Pop , V , de Keijzer , J , Hofman , A , Aulchenko , Y S , Oostra , B A , Ohlsson , C , Boomsma , D I , Uitterlinden , A G , van Duijn , C M , Rivadeneira , F F & Kayser , M 2009 , ' A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation ' , Human Molecular Genetics , vol. 18 , no. 18 , pp. 3516-3524 . https://doi.org/10.1093/hmg/ddp296
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28801291
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/b8abe358-356a-4208-ac31-3e79da00477d

Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (P