Nearly three-quarters of the 143 genetic signals associated with platelet and erythrocyte phenotypes identified by metaanalyses of genome-wide association (GWA) studies are located at non-protein-coding regions. Here, we assessed the role of candidate regulatory variants associated with cell type-restricted, closely related hematological quantitative traits in biologically relevant hematopoietic cell types. We used formaldehyde-assisted isolation of regulatory elements followed by next-generation sequencing (FAIRE-seq) to map regions of open chromatin in three primary human blood cells of the... Mehr ...
| Verfasser: |
Paul, D.S.
Albers, C.A.
Rendon, A.
Voss, K.
Stephens, J.
Akkerman, J.W.
Algra, A.
Al-Hussani, A.
Allayee, H.
Anni, F.
Asselbergs, F.W.
Attwood, A.
Balkau, B.
Bandinelli, S.
Bastardot, F.
Basu, S.
Baumeister, S.E.
Beckmann, J.
Benyamin, B.
Biino, G.
Bis, J.C.
Bomba, L.
Bonnefond, A.
Boomsma, D.I.
Bradley, J.R.
Cambien, F.
Ciullo, M.
Cookson, W.O.
Cucca, F.
Cvejic, A.
d'Adamo, A.P.
Danesh, J.
Danjou, F.
Das, D.
Davies, G.
de Bakker, P.I.
de Boer, R.A.
de Geus, E.J.C.
Deary, I.J.
Dedoussis, G.V.
Dimitriou, M.
Dina, C.
Döring, A.
Elling, U.
Ellinghaus, D.
Elliott, P.
Engström, G.
Erdmann, J.
Esko, T.
Evans, D.M.
Eyjolfsson, G.I.
Falchi, M.
Feng, W.W.
Ferreira, M.A.
Ferrucci, L.
Fischer, K.
Folsom, A.R.
Fortina, P.
Franke, A.
Franke, L.
Frazer, I.H.
Froguel, P.
Galanello, R.
Ganesh, S.
Garner, S.F.
Gasparini, P.
Genser, B.
Gibson, Q.D.
Gieger, C.
Girotto, G.
Glazer, N.L.
Gögele, M.
Goodall, A.H.
Greinacher, A.
Gudbjartsson, D.F.
Hammond, C.J.
Harris, S.E.
Hartiala, J.
Hartikainen, A.L.
Hazen, S.L.
Heckbert, S.R.
Hedblad, B.
Hengstenberg, C.
Hersch, M.
Hicks, A.A.
Holm, H.
Hottenga, J.J.
Illig, T.
Järvelin, M.R.
Jolley, J.
Jupe, S.
Kähönen, M.
Kamatani, N.
Kanoni, S.
Kema, I.P.
Kemp, J.P.
Khadake, J.
Khaw, K.T.
Kleber, M.E.
Kooner, J.S.
Kovacs, P.
Kühnel, B.
Kyrtsonis, M.C.
Labrune, Y.
Lagou, V.
Langenberg, C.
Lehtimäki, T.
Li, X.
Liang, L.
Lloyd-Jones, H.
Loos, R.J.
Lopez, L.M.
Lumley, T.
Lyytikäinen, L.P.
Maerz, W.
Mägi, R.
Mangino, M.
Martin, N.G.
Maschio, A.
Mateo Leach, I.
McKnight, B.
Meacham, S.
Medland, S.E.
Meisinger, C.
Melander, O.
Memari, Y.
Metspalu, A.
Miller, K.
Mitchell, B.D.
Moffatt, M.F.
Montgomery, G.W.
Moore, C.
Murgia, F.
Nakamura, Y.
Nauck, M.
Navis, G.
Nolte, I.M.
Nöthlings, U.
Nutile, T.
Okada, Y.
Olafsson, I.
Onundarson, P.T.
O'Reilly, P.F.
Parracciani, D.
Parsa, A.
Penninger, J.M.
Penninx, B.W.J.H.
Pirastu, M.
Pirastu, N.
Pistis, G.
Porcu, E.
Portas, L.
Porteous, D.J.
Pouta, A.
Pramstaller, P.P.
Prokopenko, I.
Psaty, B.M.
Pullat, J.
Radhakrishnan, A.
Raitakari, O.
Ramirez-Solis, R.
Ried, J.S.
Ring, S.M.
Robino, A.
Rotter, J.I.
Ruggiero, D.
Ruokonen, A.
Sala, C.
Saluments, A.
Samani, N.J.
Sambrook, J.
Sanna, S.
Schlessinger, D.
Schmidt, C.O.
Schreiber, S
Schunkert, H.
Scott, J.
Sehmi, J.
Serbanovic-Canic, J.
Shin, S.Y.
Shuldiner, A.R.
Sladek, R.
Smit, J.H.
Smith, G.D.
Smith, J.G.
Smith, N.L.
Snieder, H.
Sorice, R.
Spector, T.D.
Starr, J.M.
Stefansson, K.
Stemple, D.
Stumvoll, M.
Sulem, P.
Takahashi, A.
Tan, S.T.
Tanaka, T.
Tang, C.
Tang, W.
Tang, W.H.
Taylor, K.
Tenesa, A.
Teumer, A.
Thein, S.
Thorsteinsdottir, U.
Toniolo, D.
Tönjes, A.
Traglia, M.
Uda, M.
Ulivi, S.
van der Schoot, E.
van Gilst, W.H.
van Pelt, L.J.
van Veldhuisen, D.J.
Verweij, N.
Visscher, P.M.
Völker, U.
Vollenweider, P.
Wareham, N.J.
Wernisch, L.
Westra, H.J.
Whitfield, J.B.
Wichmann, H.E.
Wiggins, K.L.
Willemsen, G.
Winkelmann, B.R.
Wirnsberger, G.
Wolffenbuttel, B.H.
Yang, J.
Yang, T.P.
Zhang, J.H.
Zhao, J.H.
Zitting, P.
Zwaginga, JJ
van der Harst, P.
Chambers, J.C.
Soranzo, N.
Ouwehand, W.H.
Deloukas, P. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2013 |
| Reihe/Periodikum: |
Paul , D S , Albers , C A , Rendon , A , Voss , K , Stephens , J , Akkerman , J W , Algra , A , Al-Hussani , A , Allayee , H , Anni , F , Asselbergs , F W , Attwood , A , Balkau , B , Bandinelli , S , Bastardot , F , Basu , S , Baumeister , S E , Beckmann , J , Benyamin , B , Biino , G , Bis , J C , Bomba , L , Bonnefond , A , Boomsma , D I , Bradley , J R , Cambien , F , Ciullo , M , Cookson , W O , Cucca , F , Cvejic , A , d'Adamo , A P , Danesh , J , Danjou , F , Das , D , Davies , G , de Bakker , P I , de Boer , R A , de Geus , E J C , Deary , I J , Dedoussis , G V , Dimitriou , M , Dina , C , Döring , A , Elling , U , Ellinghaus , D , Elliott , P , Engström , G , Erdmann , J , Esko , T , Evans , D M , Eyjolfsson , G I , Falchi , M , Feng , W W , Ferreira , M A , Ferrucci , L , Fischer , K , Folsom , A R , Fortina , P , Franke , A , Franke , L , Frazer , I H , Froguel , P , Galanello , R , Ganesh , S , Garner , S F , Gasparini , P , Genser , B , Gibson , Q D , Gieger , C , Girotto , G , Glazer , N L , Gögele , M , Goodall , A H , Greinacher , A , Gudbjartsson , D F , Hammond , C J , Harris , S E , Hartiala , J , Hartikainen , A L , Hazen , S L , Heckbert , S R , Hedblad , B , Hengstenberg , C , Hersch , M , Hicks , A A , Holm , H , Hottenga , J J , Illig , T , Järvelin , M R , Jolley , J , Jupe , S , Kähönen , M , Kamatani , N , Kanoni , S , Kema , I P , Kemp , J P , Khadake , J , Khaw , K T , Kleber , M E , Kooner , J S , Kovacs , P , Kühnel , B , Kyrtsonis , M C , Labrune , Y , Lagou , V , Langenberg , C , Lehtimäki , T , Li , X , Liang , L , Lloyd-Jones , H , Loos , R J , Lopez , L M , Lumley , T , Lyytikäinen , L P , Maerz , W , Mägi , R , Mangino , M , Martin , N G , Maschio , A , Mateo Leach , I , McKnight , B , Meacham , S , Medland , S E , Meisinger , C , Melander , O , Memari , Y , Metspalu , A , Miller , K , Mitchell , B D , Moffatt , M F , Montgomery , G W , Moore , C , Murgia , F , Nakamura , Y , Nauck , M , Navis , G , Nolte , I M , Nöthlings , U , Nutile , T , Okada , Y , Olafsson , I , Onundarson , P T , O'Reilly , P F , Parracciani , D , Parsa , A , Penninger , J M , Penninx , B W J H , Pirastu , M , Pirastu , N , Pistis , G , Porcu , E , Portas , L , Porteous , D J , Pouta , A , Pramstaller , P P , Prokopenko , I , Psaty , B M , Pullat , J , Radhakrishnan , A , Raitakari , O , Ramirez-Solis , R , Ried , J S , Ring , S M , Robino , A , Rotter , J I , Ruggiero , D , Ruokonen , A , Sala , C , Saluments , A , Samani , N J , Sambrook , J , Sanna , S , Schlessinger , D , Schmidt , C O , Schreiber , S , Schunkert , H , Scott , J , Sehmi , J , Serbanovic-Canic , J , Shin , S Y , Shuldiner , A R , Sladek , R , Smit , J H , Smith , G D , Smith , J G , Smith , N L , Snieder , H , Sorice , R , Spector , T D , Starr , J M , Stefansson , K , Stemple , D , Stumvoll , M , Sulem , P , Takahashi , A , Tan , S T , Tanaka , T , Tang , C , Tang , W , Tang , W H , Taylor , K , Tenesa , A , Teumer , A , Thein , S , Thorsteinsdottir , U , Toniolo , D , Tönjes , A , Traglia , M , Uda , M , Ulivi , S , van der Schoot , E , van Gilst , W H , van Pelt , L J , van Veldhuisen , D J , Verweij , N , Visscher , P M , Völker , U , Vollenweider , P , Wareham , N J , Wernisch , L , Westra , H J , Whitfield , J B , Wichmann , H E , Wiggins , K L , Willemsen , G , Winkelmann , B R , Wirnsberger , G , Wolffenbuttel , B H , Yang , J , Yang , T P , Zhang , J H , Zhao , J H , Zitting , P , Zwaginga , JJ , van der Harst , P , Chambers , J C , Soranzo , N , Ouwehand , W H & Deloukas , P 2013 , ' Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci ' , Genome Research , vol. 23 , no. 7 , pp. 1130-1141 . https://doi.org/10.1101/gr.155127.113 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28800984 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/831d69d3-dda1-469b-90b6-77077520bb8d |
