C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis
Elevated C-reactive protein (CRP) concentrations in the blood are associated with acute and chronic infections and inflammation. Nevertheless, the functional role of increased CRP in multiple bacterial and viral infections as well as in chronic inflammatory diseases remains unclear. Here, we studied the relationship between CRP and gene expression levels in the blood in 491 individuals from the Estonian Biobank cohort, to elucidate the role of CRP in these inflammatory mechanisms. As a result, we identified a set of 1,614 genes associated with changes in CRP levels with a high proportion of in... Mehr ...
Verfasser: |
Lepik, Kaido
Annilo, Tarmo
Kukuškina, Viktorija
Kisand, Kai
Kutalik, Zoltán
Peterson, Pärt
Peterson, Hedi
Boomsma, D.I.
Nivard, M.G.
van Dongen, J. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Lepik , K , Annilo , T , Kukuškina , V , Kisand , K , Kutalik , Z , Peterson , P , Peterson , H , eQTLGen Consortium , Boomsma , D I , Nivard , M G & van Dongen , J 2017 , ' C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis ' , PLoS Computational Biology , vol. 13 , no. 9 , e1005766 , pp. e1005766 . https://doi.org/10.1371/journal.pcbi.1005766 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28800958 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/801a178b-3971-47cb-86fc-e90244c960f0 |