Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci
BACKGROUND: DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N = 310). RESULTS: DNA methylation at 50 CpG sites was associated (FDR < 0.05) with cotinine levels, 17 of which are novel associations. As cotinine levels are in... Mehr ...
Verfasser: |
Gupta, Richa
Van Dongen, Jenny
Fu, Yu
Abdellaoui, Abdel
Tyndale, Rachel F.
Velagapudi, Vidya
Boomsma, Dorret I.
Korhonen, Tellervo
Kaprio, Jaakko
Loukola, Anu
Ollikainen, Miina |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2019 |
Reihe/Periodikum: |
Gupta , R , Van Dongen , J , Fu , Y , Abdellaoui , A , Tyndale , R F , Velagapudi , V , Boomsma , D I , Korhonen , T , Kaprio , J , Loukola , A & Ollikainen , M 2019 , ' Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci ' , Clinical epigenetics , vol. 11 , no. 1 , 1 , pp. 1-13 . https://doi.org/10.1186/s13148-018-0606-9 |
Schlagwörter: |
Causal inference
/ Cotinine
/ Epigenome-wide association study
/ Genetic risk score
/ meQTL
/ Molecular mediation
/ Nicotine metabolism
/ Smoking
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28800540 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/38a2dd1b-475d-4a2c-9f63-0fd9c045541e |