The Genetics of the Mood Disorder Spectrum:Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
BACKGROUND: Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. METHODS: To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association... Mehr ...
Verfasser: |
Coleman, Jonathan R I
Breen, Gerome
Abdellaoui, A.
Derks, E.M.
Dolan, C.V.
Hottenga, Jouke Jan
Jansen, Rick
Mbarek, Hamdi
Middeldorp, C.M.
Milaneschi, Yuri
Nivard, Michel G.
Peyrot, Wouter J
Willemsen, Gonneke
Boomsma, D.I.
de Geus, Eco J.C.
W J H Penninx, Brenda
Posthuma, Danielle |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
Coleman , J R I , Breen , G , Bipolar Disorder Working Group of the Psychiatric Genomics Consortium , Abdellaoui , A , Derks , E M , Dolan , C V , Hottenga , J J , Jansen , R , Mbarek , H , Middeldorp , C M , Milaneschi , Y , Nivard , M G , Peyrot , W J , Willemsen , G , Boomsma , D I , de Geus , E J C , W J H Penninx , B & Posthuma , D 2020 , ' The Genetics of the Mood Disorder Spectrum : Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls ' , Biological Psychiatry , vol. 88 , no. 2 , pp. 169-184 . https://doi.org/10.1016/j.biopsych.2019.10.015 |
Schlagwörter: |
Affective disorders
/ Bipolar disorder
/ Genetic correlation
/ Genome-wide association study
/ Major depressive disorder
/ Mood disorders
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28800431 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/27d723ef-6f1b-4afb-a2ff-338058b3e20b |