GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia
Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses w... Mehr ...
Verfasser: |
Stringer, Sven
Treur, Jorien L
Abdellaoui, Abdel
Nivard, Michel G
Baselmans, Bart M L
Ip, Hill F
van der Zee, Matthijs D
Bartels, Meike
van Lier, Pol A C
Boomsma, Dorret I
Posthuma, Danielle
Derks, Eske M
Vink, Jacqueline M |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
Stringer , S , Treur , J L , Abdellaoui , A , Nivard , M G , Baselmans , B M L , Ip , H F , van der Zee , M D , Bartels , M , van Lier , P A C , Boomsma , D I , Posthuma , D , Derks , E M , Vink , J M & 23Andme Research Team 2018 , ' GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia ' , Nature Neuroscience , vol. 21 , no. 9 , pp. 1161-1170 . https://doi.org/10.1038/s41593-018-0206-1 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger
/ name=SDG 2 - Zero Hunger
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28800369 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://research.vu.nl/en/publications/1dd6950a-f952-4879-8302-ac495de5c1c3 |