INTRODUCTION: Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. METHODS: We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifest... Mehr ...
Verfasser: |
van der Lee, Sven J.
Teunissen, Charlotte E.
Pool, René
Shipley, Martin J.
Teumer, Alexander
Chouraki, Vincent
Melo van Lent, Debora
Tynkkynen, Juho
Fischer, Krista
Hernesniemi, Jussi
Haller, Toomas
Singh-Manoux, Archana
Verhoeven, Aswin
Willemsen, Gonneke
de Leeuw, Francisca A.
Wagner, Holger
van Dongen, Jenny
Hertel, Johannes
Budde, Kathrin
Willems van Dijk, Ko
Weinhold, Leonie
Ikram, M. Arfan
Pietzner, Maik
Perola, Markus
Wagner, Michael
Friedrich, Nele
Slagboom, P. Eline
Scheltens, Philip
Yang, Qiong
Gertzen, Robert E.
Egert, Sarah
Li, Shuo
Hankemeier, Thomas
van Beijsterveldt, Catharina E.M.
Vasan, Ramachandran S.
Maier, Wolfgang
Peeters, Carel F.W.
Jörgen Grabe, Hans
Ramirez, Alfredo
Seshadri, Sudha
Metspalu, Andres
Kivimäki, Mika
Salomaa, Veikko
Demirkan, Ayşe
Boomsma, Dorret I.
van der Flier, Wiesje M.
Amin, Najaf
van Duijn, Cornelia M. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
van der Lee , S J , Teunissen , C E , Pool , R , Shipley , M J , Teumer , A , Chouraki , V , Melo van Lent , D , Tynkkynen , J , Fischer , K , Hernesniemi , J , Haller , T , Singh-Manoux , A , Verhoeven , A , Willemsen , G , de Leeuw , F A , Wagner , H , van Dongen , J , Hertel , J , Budde , K , Willems van Dijk , K , Weinhold , L , Ikram , M A , Pietzner , M , Perola , M , Wagner , M , Friedrich , N , Slagboom , P E , Scheltens , P , Yang , Q , Gertzen , R E , Egert , S , Li , S , Hankemeier , T , van Beijsterveldt , C E M , Vasan , R S , Maier , W , Peeters , C F W , Jörgen Grabe , H , Ramirez , A , Seshadri , S , Metspalu , A , Kivimäki , M , Salomaa , V , Demirkan , A , Boomsma , D I , van der Flier , W M , Amin , N & van Duijn , C M 2018 , ' Circulating metabolites and general cognitive ability and dementia : Evidence from 11 cohort studies ' , Alzheimers & Dementia , vol. 14 , no. 6 , pp. 707-722 . https://doi.org/10.1016/j.jalz.2017.11.012 |
Schlagwörter: |
Alzheimer's disease
/ Cognitive function
/ Dementia
/ General cognitive ability
/ Lifestyle factors
/ Metabolites
/ Metabolomics
/ NMR
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28800364 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://research.vu.nl/en/publications/1d0cf916-c930-4582-a3b6-5ea259dfb968 |