Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 - 10 g8). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the ful... Mehr ...

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Verfasser: Stolk, L.
Perry, J.R.B.
Chasman, D.I.
He, C.
Mangino, M.
Sulem, P.
Barbalic, M.
Broer, L.
Byrne, E.M.
Ernst, F.
Esko, T.
Franceschini, N.
Gudbjartsson, D.F.
Hottenga, J.J.
Kraft, P.
McArdle, P.F.
Porcu, E.
Shin, S.Y.
Smith, A.V.
van Wingerden, S.
Zhai, G.
Zhuang, W.V.
Albrecht, E.
Alizadeh, BZ
Aspelund, T.
de Geus, E.J.C.
Vink, J.M.
Willemsen, G.
Boomsma, D.I.
Crisponi, L.
Demerath, E.W.
Gudnason, V.
Harris, T.B.
Hu, F.B.
Hunter, D.J.
Launer, L.J.
Metspalu, A.
Montgomery, G.W.
Oostra, B.A.
Ridker, P.M.
Sanna, S.
Schlessinger, D.
Spector, T.D.
Stefansson, K.
Streeten, E.A.
Thorsteinsdottir, U.
Uda, M.
Uitterlinden, A.G.
van Duijn, C.M.
Völzke, H.
Murray, A.
Murabito, J.M.
Visser, J.A.
Lunetta, K.L.
Dokumenttyp: Artikel
Erscheinungsdatum: 2012
Reihe/Periodikum: Stolk , L , Perry , J R B , Chasman , D I , He , C , Mangino , M , Sulem , P , Barbalic , M , Broer , L , Byrne , E M , Ernst , F , Esko , T , Franceschini , N , Gudbjartsson , D F , Hottenga , J J , Kraft , P , McArdle , P F , Porcu , E , Shin , S Y , Smith , A V , van Wingerden , S , Zhai , G , Zhuang , W V , Albrecht , E , Alizadeh , BZ , Aspelund , T , de Geus , E J C , Vink , J M , Willemsen , G , Boomsma , D I , Crisponi , L , Demerath , E W , Gudnason , V , Harris , T B , Hu , F B , Hunter , D J , Launer , L J , Metspalu , A , Montgomery , G W , Oostra , B A , Ridker , P M , Sanna , S , Schlessinger , D , Spector , T D , Stefansson , K , Streeten , E A , Thorsteinsdottir , U , Uda , M , Uitterlinden , A G , van Duijn , C M , Völzke , H , Murray , A , Murabito , J M , Visser , J A & Lunetta , K L 2012 , ' Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways ' , Nature Genetics , vol. 44 , no. 3 , pp. 260-268 . https://doi.org/10.1038/ng.1051
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28800059
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/0a1d95cb-f10c-4482-ba7f-dabac0d4b60a

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 - 10 g8). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-I °B signaling and mitochondrial dysfunction as biological processes related to timing of menopause. © 2012 Nature America, Inc. All rights reserved.