Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new... Mehr ...
Verfasser: |
Wain, Louise V
Vaez, Ahmad
Jansen, Rick
Joehanes, Roby
van der Most, Peter J
Erzurumluoglu, A Mesut
O'Reilly, Paul F
Cabrera, Claudia P
Warren, Helen R
Rose, Lynda M
Verwoert, Germaine C
Hottenga, Jouke-Jan
Strawbridge, Rona J
Esko, Tonu
Arking, Dan E
Hwang, Shih-Jen
Guo, Xiuqing
Kutalik, Zoltan
Trompet, Stella
Shrine, Nick
Teumer, Alexander
Ried, Janina S
Bis, Joshua C
Smith, Albert V
Amin, Najaf
Nolte, Ilja M
Lyytikäinen, Leo-Pekka
Mahajan, Anubha
Wareham, Nicholas J
Hofer, Edith
Joshi, Peter K
Kristiansson, Kati
Traglia, Michela
Havulinna, Aki S
Goel, Anuj
Nalls, Mike A
Sõber, Siim
Vuckovic, Dragana
Luan, Jian'an
Del Greco M, Fabiola
Ayers, Kristin L
Marrugat, Jaume
Ruggiero, Daniela
Lopez, Lorna M
Niiranen, Teemu
Enroth, Stefan
Jackson, Anne U
Nelson, Christopher P
Huffman, Jennifer E
Zhang, Weihua
Marten, Jonathan
Gandin, Ilaria
Harris, Sarah E
Zemunik, Tatijana
Lu, Yingchang
Evangelou, Evangelos
Shah, Nabi
de Borst, Martin H
Mangino, Massimo
Prins, Bram P
Campbell, Archie
Li-Gao, Ruifang
Chauhan, Ganesh
Oldmeadow, Christopher
Abecasis, Gonçalo R
Abedi, Maryam
Barbieri, Caterina M
Barnes, Michael R
Batini, Chiara
Beilby, John
Blake, Tineka
Boehnke, Michael
Bottinger, Erwin P
Braund, Peter S
Brown, Morris
Brumat, Marco
Campbell, Harry
Chambers, John C
Cocca, Massimiliano
Collins, Francis S
Connell, John
Cordell, Heather J
Damman, Jeffrey J
Davies, Gail
de Geus, Eco J
de Mutsert, Renée
Deelen, Joris
Demirkale, Yusuf
Doney, Alex S F
Dörr, Marcus
Farrall, Martin
Ferreira, Teresa
Frånberg, Mattias
Gao, He
Giedraitis, Vilmantas
Gieger, Christian
Giulianini, Franco
Gow, Alan J
Hamsten, Anders
Harris, Tamara B
Hofman, Albert
Holliday, Elizabeth G
Hui, Jennie
Jarvelin, Marjo-Riitta
Johansson, Åsa
Johnson, Andrew D
Jousilahti, Pekka
Jula, Antti
Kähönen, Mika
Kathiresan, Sekar
Khaw, Kay-Tee
Kolcic, Ivana
Koskinen, Seppo
Langenberg, Claudia
Larson, Marty
Launer, Lenore J
Lehne, Benjamin
Liewald, David C M
Lin, Li
Lind, Lars
Mach, François
Mamasoula, Chrysovalanto
Menni, Cristina
Mifsud, Borbala
Milaneschi, Yuri
Morgan, Anna
Morris, Andrew D
Morrison, Alanna C
Munson, Peter J
Nandakumar, Priyanka
Nguyen, Quang Tri
Nutile, Teresa
Oldehinkel, Albertine J
Oostra, Ben A
Org, Elin
Padmanabhan, Sandosh
Palotie, Aarno
Paré, Guillaume
Pattie, Alison
Penninx, Brenda W J H
Poulter, Neil
Pramstaller, Peter P
Raitakari, Olli T
Ren, Meixia
Rice, Kenneth
Ridker, Paul M
Riese, Harriëtte
Ripatti, Samuli
Robino, Antonietta
Rotter, Jerome I
Rudan, Igor
Saba, Yasaman
Saint Pierre, Aude
Sala, Cinzia F
Sarin, Antti-Pekka
Schmidt, Reinhold E
Scott, Rodney J
Seelen, Marc A
Shields, Denis C
Siscovick, David
Sorice, Rossella
Stanton, Alice
Stott, David J
Sundström, Johan
Swertz, Morris a.
Taylor, Kent D
Thom, Simon
Tzoulaki, Ioanna
Tzourio, Christophe
Uitterlinden, André G
Völker, Uwe
Vollenweider, Peter
Wild, Sarah
Willemsen, Gonneke
Wright, Alan F
Yao, Jie
Thériault, Sébastien
Conen, David
Attia, John R
Sever, Peter
Debette, Stéphanie
Mook-Kanamori, Dennis O
Zeggini, Eleftheria
Spector, Tim D
van der Harst, Pim
Palmer, Colin N A
Vergnaud, Anne-Claire
Loos, Ruth J F
Polasek, Ozren
Starr, John M
Girotto, Giorgia
Hayward, Caroline
Kooner, Jaspal S
Lindgren, Cecila M
Vitart, Veronique
Samani, Nilesh J
Tuomilehto, Jaakko
Gyllensten, Ulf
Knekt, Paul
Deary, Ian J
Ciullo, Marina
Elosua, Roberto
Keavney, Bernard D
Hicks, Andrew A
Scott, Robert A
Gasparini, Paolo
Laan, Maris
Liu, YongMei
Watkins, Hugh
Hartman, Catharina A
Salomaa, Veikko
Toniolo, Daniela
Perola, Markus
Wilson, James F
Schmidt, Helena
Zhao, Jing Hua
Lehtimäki, Terho
van Duijn, Cornelia M
Gudnason, Vilmundur
Psaty, Bruce M
Peters, Annette
Rettig, Rainer
James, Alan L
Jukema, J Wouter
Strachan, David P
Palmas, Walter
Metspalu, Andres
Ingelsson, Erik
Boomsma, Dorret I
Franco, Oscar H
Bochud, Murielle
Newton-Cheh, Christopher
Munroe, Patricia B
Elliott, Paul
Chasman, Daniel I
Chakravarti, Aravinda
Knight, Joanne
Morris, Andrew P
Levy, Daniel
Tobin, Martin D
Snieder, Harold
Caulfield, Mark J
Ehret, Georg B |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Wain , L V , Vaez , A , Jansen , R , Joehanes , R , van der Most , P J , Erzurumluoglu , A M , O'Reilly , P F , Cabrera , C P , Warren , H R , Rose , L M , Verwoert , G C , Hottenga , J-J , Strawbridge , R J , Esko , T , Arking , D E , Hwang , S-J , Guo , X , Kutalik , Z , Trompet , S , Shrine , N , Teumer , A , Ried , J S , Bis , J C , Smith , A V , Amin , N , Nolte , I M , Lyytikäinen , L-P , Mahajan , A , Wareham , N J , Hofer , E , Joshi , P K , Kristiansson , K , Traglia , M , Havulinna , A S , Goel , A , Nalls , M A , Sõber , S , Vuckovic , D , Luan , J , Del Greco M , F , Ayers , K L , Marrugat , J , Ruggiero , D , Lopez , L M , Niiranen , T , Enroth , S , Jackson , A U , Nelson , C P , Huffman , J E , Zhang , W , Marten , J , Gandin , I , Harris , S E , Zemunik , T , Lu , Y , Evangelou , E , Shah , N , de Borst , M H , Mangino , M , Prins , B P , Campbell , A , Li-Gao , R , Chauhan , G , Oldmeadow , C , Abecasis , G R , Abedi , M , Barbieri , C M , Barnes , M R , Batini , C , Beilby , J , Blake , T , Boehnke , M , Bottinger , E P , Braund , P S , Brown , M , Brumat , M , Campbell , H , Chambers , J C , Cocca , M , Collins , F S , Connell , J , Cordell , H J , Damman , J J , Davies , G , de Geus , E J , de Mutsert , R , Deelen , J , Demirkale , Y , Doney , A S F , Dörr , M , Farrall , M , Ferreira , T , Frånberg , M , Gao , H , Giedraitis , V , Gieger , C , Giulianini , F , Gow , A J , Hamsten , A , Harris , T B , Hofman , A , Holliday , E G , Hui , J , Jarvelin , M-R , Johansson , Å , Johnson , A D , Jousilahti , P , Jula , A , Kähönen , M , Kathiresan , S , Khaw , K-T , Kolcic , I , Koskinen , S , Langenberg , C , Larson , M , Launer , L J , Lehne , B , Liewald , D C M , Lin , L , Lind , L , Mach , F , Mamasoula , C , Menni , C , Mifsud , B , Milaneschi , Y , Morgan , A , Morris , A D , Morrison , A C , Munson , P J , Nandakumar , P , Nguyen , Q T , Nutile , T , Oldehinkel , A J , Oostra , B A , Org , E , Padmanabhan , S , Palotie , A , Paré , G , Pattie , A , Penninx , B W J H , Poulter , N , Pramstaller , P P , Raitakari , O T , Ren , M , Rice , K , Ridker , P M , Riese , H , Ripatti , S , Robino , A , Rotter , J I , Rudan , I , Saba , Y , Saint Pierre , A , Sala , C F , Sarin , A-P , Schmidt , R E , Scott , R J , Seelen , M A , Shields , D C , Siscovick , D , Sorice , R , Stanton , A , Stott , D J , Sundström , J , Swertz , M A , Taylor , K D , Thom , S , Tzoulaki , I , Tzourio , C , Uitterlinden , A G , Völker , U , Vollenweider , P , Wild , S , Willemsen , G , Wright , A F , Yao , J , Thériault , S , Conen , D , Attia , J R , Sever , P , Debette , S , Mook-Kanamori , D O , Zeggini , E , Spector , T D , van der Harst , P , Palmer , C N A , Vergnaud , A-C , Loos , R J F , Polasek , O , Starr , J M , Girotto , G , Hayward , C , Kooner , J S , Lindgren , C M , Vitart , V , Samani , N J , Tuomilehto , J , Gyllensten , U , Knekt , P , Deary , I J , Ciullo , M , Elosua , R , Keavney , B D , Hicks , A A , Scott , R A , Gasparini , P , Laan , M , Liu , Y , Watkins , H , Hartman , C A , Salomaa , V , Toniolo , D , Perola , M , Wilson , J F , Schmidt , H , Zhao , J H , Lehtimäki , T , van Duijn , C M , Gudnason , V , Psaty , B M , Peters , A , Rettig , R , James , A L , Jukema , J W , Strachan , D P , Palmas , W , Metspalu , A , Ingelsson , E , Boomsma , D I , Franco , O H , Bochud , M , Newton-Cheh , C , Munroe , P B , Elliott , P , Chasman , D I , Chakravarti , A , Knight , J , Morris , A P , Levy , D , Tobin , M D , Snieder , H , Caulfield , M J & Ehret , G B 2017 , ' Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney ' , Hypertension , vol. 70 , no. 3 , pp. e4-e19 . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28799943 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/f97ede6d-1444-473e-a7e0-ea4f7f50dc9d |