Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome- and metabolome-wide significant (Z-test, P<1.09 × 10 -9 ) associations between single-nucleotide polymorphisms (SNPs) and metabolites, involving 59 independent SNPs and 85 metabolites. Five... Mehr ...
| Verfasser: |
Draisma, H.H.M.
Pool, R.
Kobl, M.
Jansen, R.
Petersen, A.K.
Vaarhorst, A.A.M.
Yet, I.
Haller, T.
Demirkan, A.
Esko, T.
Zhu, G.
Böhringer, S.
Beekman, M.
van Klinken, J.B.
Römisch-Margl, W.
Prehn, C.
Adamski, J.
de Craen, A.J.
van Leeuwen, E.M.
Amin, N.
Dharuri, H.
Westra, H.J.
Franke, L.
de Geus, E.J.C.
Hottenga, J.J.
Willemsen, G.
Henders, A.K.
Montgomery, G.W.
Nyholt, DR
Whitfield, J.B.
Penninx, B.W.J.H.
Spector, T.D.
Metspalu, A.
Slagboom, P.E.
Willems van Dijk, K.
't Hoen, P.A.C.
Strauch, K.
Martin, N.G.
van Ommen, G.J.B
Illig, T.
Bell, J.T.
Mangino, M.
Suhre, K.
McCarthy, M.I.
Gieger, C.
Isaacs, A.
van Duijn, C.M.
Boomsma, D.I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2015 |
| Reihe/Periodikum: |
Draisma , H H M , Pool , R , Kobl , M , Jansen , R , Petersen , A K , Vaarhorst , A A M , Yet , I , Haller , T , Demirkan , A , Esko , T , Zhu , G , Böhringer , S , Beekman , M , van Klinken , J B , Römisch-Margl , W , Prehn , C , Adamski , J , de Craen , A J , van Leeuwen , E M , Amin , N , Dharuri , H , Westra , H J , Franke , L , de Geus , E J C , Hottenga , J J , Willemsen , G , Henders , A K , Montgomery , G W , Nyholt , DR , Whitfield , J B , Penninx , B W J H , Spector , T D , Metspalu , A , Slagboom , P E , Willems van Dijk , K , 't Hoen , P A C , Strauch , K , Martin , N G , van Ommen , G J B , Illig , T , Bell , J T , Mangino , M , Suhre , K , McCarthy , M I , Gieger , C , Isaacs , A , van Duijn , C M & Boomsma , D I 2015 , ' Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels ' , Nature Communications , vol. 6 , 7208 , pp. 7208 . https://doi.org/10.1038/ncomms8208 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28799735 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/df4d4dda-472b-4748-9ab7-83f2f17989d4 |
