Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To interrogate the causal relationship between triglyceride, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels and genome-wide DNA methylation while excluding confounding and pleiotropy, we perform a stepwise Mendelian randomization analysis in whole blood... Mehr ...
| Verfasser: |
Dekkers, K.F.
van Iterson, M.
Slieker, R.C.
Moed, M.H.
Bonder, M.J.
van Galen, M.
Mei, H.
Zhernakova, D.V.
Van den Berg, L.H.
Deelen, J.
van Dongen, J.
van Heemst, D.
Hofman, A.
Hottenga, J.J.
van der Kallen, C.J.H.
Schalkwijk, C.G.
Stehouwer, C.D.A.
Tigchelaar, E.F.
Uitterlinden, A.G.
Willemsen, G.
Zhernakova, A.
Franke, L.
't Hoen, P.A.C.
Jansen, R.
van Meurs, J.
Boomsma, D.I.
van Duijn, C.M.
van Greevenbroek, M.M.J.
Veldink, J.H.
Wijmenga, C.
van Zwet, E.W.
Slagboom, P.E.
Jukema, J.W.
Heijmans, B.T. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2016 |
| Reihe/Periodikum: |
Dekkers , K F , van Iterson , M , Slieker , R C , Moed , M H , Bonder , M J , van Galen , M , Mei , H , Zhernakova , D V , Van den Berg , L H , Deelen , J , van Dongen , J , van Heemst , D , Hofman , A , Hottenga , J J , van der Kallen , C J H , Schalkwijk , C G , Stehouwer , C D A , Tigchelaar , E F , Uitterlinden , A G , Willemsen , G , Zhernakova , A , Franke , L , 't Hoen , P A C , Jansen , R , van Meurs , J , Boomsma , D I , van Duijn , C M , van Greevenbroek , M M J , Veldink , J H , Wijmenga , C , van Zwet , E W , Slagboom , P E , Jukema , J W & Heijmans , B T 2016 , ' Blood lipids influence DNA methylation in circulating cells ' , Genome Biology , vol. 17 , no. 138 , pp. 1-12 . https://doi.org/10.1186/s13059-016-1000-6 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28799519 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/c3f9e899-2e3b-4226-a8ce-2f9952c9c0d9 |
