A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci... Mehr ...

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Verfasser: Palmer, N.D.
McDonough, C.W.
Hicks, P.J.
Roh, B.H.
Wing, M.R.
Sandy An, S.
Hester, J.M.
Cooke, J.N.
Bostrom, M.A.
Rudock, M.E.
Talbert, M.E.
Lewis, J.P.
Hottenga, J.J.
de Geus, E.J.C.
Willemsen, G.
Boomsma, D.I.
Ferrara, A.
Lu, L.
Ziegler, J.T.
Sale, M.M.
Divers, J.
Shriner, D.
Adeyemo, A.
Rotimi, C.N.
Ng, M.C.Y.
Langefeld, C.D.
Freedman, B.I.
Bowden, D.W.
Posthuma, D.
Penninx, B.W.J.H.
Sladek, R.
Dokumenttyp: Artikel
Erscheinungsdatum: 2012
Reihe/Periodikum: Palmer , N D , McDonough , C W , Hicks , P J , Roh , B H , Wing , M R , Sandy An , S , Hester , J M , Cooke , J N , Bostrom , M A , Rudock , M E , Talbert , M E , Lewis , J P , Hottenga , J J , de Geus , E J C , Willemsen , G , Boomsma , D I , Ferrara , A , Lu , L , Ziegler , J T , Sale , M M , Divers , J , Shriner , D , Adeyemo , A , Rotimi , C N , Ng , M C Y , Langefeld , C D , Freedman , B I , Bowden , D W , Posthuma , D , Penninx , B W J H & Sladek , R 2012 , ' A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans ' , PLoS ONE , vol. 7 , no. 1 , e29202 , pp. e29202 . https://doi.org/10.1371/journal.pone.0029202
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-28799480
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/c05e6f17-de6e-4de5-9daf-94e3fb6ac780

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10