Importance: The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. Objective: To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin). Design, Setting, and Patients: This multicenter study assembled genome-wide genotypic an... Mehr ...
Verfasser: |
Milaneschi, Yuri
Lamers, Femke
Peyrot, Wouter J
Baune, Bernhard T
Breen, Gerome
Dehghan, Abbas
Forstner, Andreas J
Grabe, Hans J
Homuth, Georg
Kan, Carol
Lewis, Cathryn M
Mullins, Niamh
Nauck, Matthias
Pistis, Giorgio
Preisig, Martin
Rivera, Margarita
Rietschel, Marcella
Streit, Fabian
Strohmaier, Jana
Teumer, Alexander
Van der Auwera, Sandra
Wray, Naomi R
Boomsma, Dorret I
Penninx, Brenda W J H |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Milaneschi , Y , Lamers , F , Peyrot , W J , Baune , B T , Breen , G , Dehghan , A , Forstner , A J , Grabe , H J , Homuth , G , Kan , C , Lewis , C M , Mullins , N , Nauck , M , Pistis , G , Preisig , M , Rivera , M , Rietschel , M , Streit , F , Strohmaier , J , Teumer , A , Van der Auwera , S , Wray , N R , Boomsma , D I , Penninx , B W J H & CHARGE Inflammation Working Group and the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2017 , ' Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations ' , JAMA Psychiatry , vol. 74 , no. 12 , pp. 1214-1225 . https://doi.org/10.1001/jamapsychiatry.2017.3016 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28798860 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://research.vu.nl/en/publications/819fc6eb-572f-4945-aec6-06ea3e1d4fea |