A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to dep... Mehr ...
Verfasser: |
Shen, Xueyi
McIntosh, Andrew M
Abdellaoui, A.
Derks, Eske M.
Dolan, C.V.
Hottenga, Jouke Jan
Jansen, Rick
Mbarek, Hamdi
Middeldorp, C.M.
Nivard, Michel
Peyrot, Wouter J
Posthuma, Danielle
Willemsen, Gonneke
Boomsma, D.I.
de Geus, Eco J.C.
W J H Penninx, Brenda |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
Shen , X , McIntosh , A M , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium , Abdellaoui , A , Derks , E M , Dolan , C V , Hottenga , J J , Jansen , R , Mbarek , H , Middeldorp , C M , Nivard , M , Peyrot , W J , Posthuma , D , Willemsen , G , Boomsma , D I , de Geus , E J C & W J H Penninx , B 2020 , ' A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank ' , Nature Communications , vol. 11 , no. 1 , 2301 , pp. 2301 . https://doi.org/10.1038/s41467-020-16022-0 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28798647 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/67b894f3-17cf-4a89-9412-2ee25b56b461 |