Vitamin D receptor gene polymorphisms have negligible effect on human height.
Human height is a highly heritable trait, with genetic factors explaining up to 90% of phenotypic variation. Vitamin D levels are known to influence several physiological processes, including skeletal growth. The vitamin D receptor (VDR) gene has been reported as contributing to variation in height. A meta-analysis of 13607 adult individuals found a small but significant association with the rs1544410 (BsmI) polymorphism. In contrast, the meta-analysis found no effect in a sample of 550 children. Two recent studies reported variants with large effect on height elsewhere in VDR (rs10735810 [Fok... Mehr ...
Verfasser: |
Macgregor, S.
Hottenga, J.J.
Lind, P.A.
Suchiman, E.
Willemsen, G.
Slagboom, P.E.
Montgomery, GW
Martin, N.G.
Visscher, P.M.
Boomsma, D.I. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2008 |
Reihe/Periodikum: |
Macgregor , S , Hottenga , J J , Lind , P A , Suchiman , E , Willemsen , G , Slagboom , P E , Montgomery , GW , Martin , N G , Visscher , P M & Boomsma , D I 2008 , ' Vitamin D receptor gene polymorphisms have negligible effect on human height. ' , Twin Research and Human Genetics , vol. 11 , no. 5 , pp. 488-494 . https://doi.org/10.1375/twin.11.5.488 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28798626 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/65f686f6-8b0a-4f9d-87c9-d9829c299e55 |