We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA methylation data from peripheral leukocytes were obtained using the Infinium Human Methylation 450k BeadChip. The epigenome-wide association study meta-analysis identified 39 BP-related CpG sites with P<1×10-5. In silico replication in the CHARGE consortium of 17 010 individuals validated 16 of these CpG sites. Out of the 16 CpG sites, 13 showed novel association with BP. Conversely, out of the 126 CpG sites identified as b... Mehr ...
| Verfasser: |
Huang, Yisong
Ollikainen, Miina
Muniandy, Maheswary
Zhang, Tao
van Dongen, Jenny
Hao, Guang
van der Most, Peter J.
Pan, Yue
Pervjakova, Natalia
Sun, Yan V.
Hui, Qin
Lahti, Jari
Fraszczyk, Eliza
Lu, Xueling
Sun, Dianjianyi
Richard, Melissa A.
Willemsen, Gonneke
Heikkila, Kauko
Mateo Leach, Irene
Mononen, Nina
Kähönen, Mika
Hurme, Mikko A.
Raitakari, Olli T.
Drake, Amanda J.
Perola, Markus
Nuotio, Marja Liisa
Huang, Yunfeng
Khulan, Batbayar
Räikkönen, Katri
Wolffenbuttel, Bruce H.R.
Zhernakova, Alexandra
Fu, Jingyuan
Zhu, Haidong
Dong, Yanbin
van Vliet-Ostaptchouk, Jana V.
Franke, Lude
Eriksson, Johan G.
Fornage, Myriam
Milani, Lili
Lehtimäki, Terho
Vaccarino, Viola
Boomsma, Dorret I.
van der Harst, Pim
de Geus, Eco J.C.
Salomaa, Veikko
Li, Shengxu
Chen, Wei
Su, Shaoyong
Wilson, James
Snieder, Harold
Kaprio, Jaakko
Wang, Xiaoling |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2020 |
| Reihe/Periodikum: |
Huang , Y , Ollikainen , M , Muniandy , M , Zhang , T , van Dongen , J , Hao , G , van der Most , P J , Pan , Y , Pervjakova , N , Sun , Y V , Hui , Q , Lahti , J , Fraszczyk , E , Lu , X , Sun , D , Richard , M A , Willemsen , G , Heikkila , K , Mateo Leach , I , Mononen , N , Kähönen , M , Hurme , M A , Raitakari , O T , Drake , A J , Perola , M , Nuotio , M L , Huang , Y , Khulan , B , Räikkönen , K , Wolffenbuttel , B H R , Zhernakova , A , Fu , J , Zhu , H , Dong , Y , van Vliet-Ostaptchouk , J V , Franke , L , Eriksson , J G , Fornage , M , Milani , L , Lehtimäki , T , Vaccarino , V , Boomsma , D I , van der Harst , P , de Geus , E J C , Salomaa , V , Li , S , Chen , W , Su , S , Wilson , J , Snieder , H , Kaprio , J & Wang , X 2020 , ' Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure ' , Hypertension , vol. 76 , no. 1 , pp. 195-205 . https://doi.org/10.1161/HYPERTENSIONAHA.120.14973 |
| Schlagwörter: |
blood pressure
/ DNA methylation
/ epigenome
/ hypertension
/ Twin study
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28798559 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/5ed100cb-c02e-4d87-89dd-6098f8293e36 |
