Novel variants in growth differentiation factor 9 in mothers of dizygotic twins.
Context: Genes from the ovarian bone morphogenetic signaling pathway (GDF9 and BMP15) are critical for normal human fertility. We previously identified a deletion mutation in GDF9 in sisters with spontaneous dizygotic (DZ) twins, but the prevalence of rare GDF9 variants in twinning families is unknown. Objective: The objective was to evaluate the frequency of rare variants in GDF9 in families with a history of DZ twinning. Design and Subjects: We recruited 3450 individuals from 915 DZ twinning families (1693 mothers of twins) and 1512 controls of Caucasian origin. One mother of DZ twins was se... Mehr ...
Verfasser: |
Palmer, JS
Zhao, Z.Z.
Hoekstra, C.
Hayward, N.K.
Webb, P.M.
Whiteman, D.C.
Martin, N.G.
Boomsma, D.I.
Duffy, DL
Montgomery, GW |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2006 |
Reihe/Periodikum: |
Palmer , JS , Zhao , Z Z , Hoekstra , C , Hayward , N K , Webb , P M , Whiteman , D C , Martin , N G , Boomsma , D I , Duffy , DL & Montgomery , GW 2006 , ' Novel variants in growth differentiation factor 9 in mothers of dizygotic twins. ' , Journal of Clinical Endocrinology and Metabolism , vol. 91 , no. 11 , pp. 4713-4716 . https://doi.org/10.1210/jc.2006-0970 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28797762 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/0f705b16-4f41-49e9-8791-53da285bed12 |