Metabolomics Profile in Depression:A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls
BACKGROUND: Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers, predominantly lipids, was compared between depressed and nondepressed persons. METHODS: Nine Dutch cohorts were included, comprising 10,145 control subjects and 5283 persons with depression, established with diagnostic interviews or questionnaires. A proton nuclear magnetic resonance metabolomics platform provided 230 metabolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and partic... Mehr ...
Verfasser: |
Bot, Mariska
Milaneschi, Yuri
Pool, Rene
Ligthart, Lannie
Boomsma, Dorret I
Penninx, Brenda W J H |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
Bot , M , Milaneschi , Y , Pool , R , Ligthart , L , Boomsma , D I , Penninx , B W J H & BBMRI-NL Metabolomics Consortium 2020 , ' Metabolomics Profile in Depression : A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls ' , Biological Psychiatry , vol. 87 , no. 5 , pp. 409-418 . https://doi.org/10.1016/j.biopsych.2019.08.016 |
Schlagwörter: |
Biomarkers
/ Cardiovascular
/ Depression
/ Metabolites
/ Metabolomics
/ Pooled analysis
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28797715 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/09cd043a-37e7-4ac0-be42-2b5efff3847d |