Characterizing the Relation Between Expression QTLs and Complex Traits:Exploring the Role of Tissue Specificity
Measurement of gene expression levels and detection of eQTLs (expression quantitative trait loci) are difficult in tissues with limited sample availability, such as the brain. However, eQTL overlap between tissues might be high, which would allow for inference of eQTL functioning in the brain via eQTLs detected in readily accessible tissues, e.g. whole blood. Applying Stratified Linkage Disequilibrium Score Regression (SLDSR), we quantified the enrichment in polygenic signal of blood and brain eQTLs in genome-wide association studies (GWAS) of 11 complex traits. We looked at eQTLs discovered i... Mehr ...
Verfasser: |
Ip, Hill F.
Jansen, Rick
Abdellaoui, Abdel
Bartels, Meike
Boomsma, Dorret I.
Nivard, Michel G. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
Ip , H F , Jansen , R , Abdellaoui , A , Bartels , M , Boomsma , D I , Nivard , M G & UK Brain Expression Consortium 2018 , ' Characterizing the Relation Between Expression QTLs and Complex Traits : Exploring the Role of Tissue Specificity ' , Behavior Genetics , vol. 48 , no. 5 , pp. 374-385 . https://doi.org/10.1007/s10519-018-9914-2 |
Schlagwörter: |
Brain
/ Complex human traits
/ Enrichment
/ eQTL discovery
/ Gene expression
/ Genome-wide
/ SLDSR
/ Stratified linkage disequilibrium score regression
/ Tissue-specificity
/ Whole blood
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28797651 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://research.vu.nl/en/publications/030b64a0-05a4-4344-b7f0-1609763d6d16 |