Water related problems caused by climate change are threatening the future of food systems in both Netherlands and Ghana. In this paper we present the results of a comparative case study analysis. The objective is identifying similarities in the use of spatial information by experts and stakeholders in their attempts to remove the barriers or foster the enablers of NbS uptake in view of climate change. Experiences in this field have been listed in the Rhine-Scheldt Estuaries (the Netherlands) and Bono East Region (Ghana) about rainwater harvesting and reuse of wastewater. The analysis focused on identifying similarities in the use of spatial information by stakeholders in their attempts to remove the barriers or foster the enablers of NBS uptake. Both rainwater harvesting and wastewater treatment techniques are available, and ready to be accepted and applied by farmers and food processing industry. Their uptake however is hampered by multiple barriers, ranging from biophysical and technical barriers to social and institutional barriers. We conclude that spatial information can be an enabler for adoption of nature-based solutions, if the spatial information is applicable for the assessment of a wide range of possible solutions for water scarcity considering food production, either nature-based solutions or technologies. In both case studies we observe a struggle to make the future spatially explicit. In both case studies, the effect on biodiversity of respectively reuse of effluent water and RWH did not play a direct role in the stakeholder dialogue.