Estimating adjuvant treatment effects in Stage II colon cancer: Comparing the synthesis of randomized clinical trial data to real-world data
There is an ongoing discussion regarding the impact of adjuvant chemotherapy in Stage II colon cancer. We therefore estimated adjuvant treatment effect in Stage II colon cancer using pooled disease-free survival (DFS) data from randomized clinical trials (RCT approach) and compared this to real-world data (RWD approach) estimates. First, we estimated the treatment effect in RCTs by (i) searching relevant trials reporting DFS data, (ii) generating patient-level data from reported DFS data and (iii) estimating treatment effect in the patient-level data. Second, the treatment effect was estimated... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2020 |
Schlagwörter: | adjuvant chemotherapy / colon cancer / randomized clinical trial / real-world data / treatment effect / Organoplatinum Compounds/therapeutic use / Humans / Male / Chemotherapy / Adjuvant/methods / Randomized Controlled Trials as Topic / Antineoplastic Combined Chemotherapy Protocols/therapeutic use / Disease-Free Survival / Fluorouracil/therapeutic use / Netherlands / Female / Neoplasm Staging / Colonic Neoplasms/drug therapy / Leucovorin/therapeutic use / Oncology / Cancer Research / Research Support / Non-U.S. Gov't / Journal Article / Comparative Study |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28790761 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/441785 |