Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors
BACKGROUND: Hodgkin lymphoma (HL) survivors are at increased risk of second malignancies, but few studies have assessed colorectal cancer (CRC) risk after HL treatment. We assessed long-term, subsite-specific CRC risk associated with specific radiation fields and chemotherapy regimens. METHODS: In a Dutch cohort of 3121 5-year HL survivors treated between 1965 and 1995, subsite-specific CRC incidence was compared with general population rates. Treatment effects were quantified by Cox regression analyses. RESULTS: After a median follow-up of 22.9 years, 55 patients developed CRC. The standardiz... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2017 |
Schlagwörter: | Adult / Antineoplastic Agents/administration & dosage / Antineoplastic Combined Chemotherapy Protocols/therapeutic use / Bleomycin/therapeutic use / Colon / Colorectal Neoplasms/epidemiology / Diaphragm / Doxorubicin/therapeutic use / Female / Follow-Up Studies / Hodgkin Disease/drug therapy / Humans / Male / Mechlorethamine/therapeutic use / Middle Aged / Neoplasms / Radiation-Induced/epidemiology / Second Primary/epidemiology / Netherlands/epidemiology / Prednisone/therapeutic use / Procarbazine/administration & dosage / Rectum / Risk Factors / Survivors / Vinblastine/therapeutic use / Vincristine/therapeutic use / Young Adult / Taverne |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28790474 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/428442 |