Abstract The first millennium AD encompasses the Roman period (12 BC to AD 450) and the Early Middle Ages (AD 450 to 1050). In the Netherlands, this millennium saw population growth, steep decline and subsequent revival. In addition, many changes occurred in the physical landscape, marking a transition from a mainly natural prehistorical lowland landscape to an increasingly human-affected landscape. This paper synthesises the main landscape changes and human–landscape interactions in the Netherlands during this dynamic period. The degree of landscape change is compared between the coastal plain, the delta and the Pleistocene sand area. Human activities caused major often unintended geomorphological changes in all studied landscapes. Landscape sensitivity to human impact, however, strongly varied as a function of preceding landscape state. The most prominent changes took place in many parts of the coastal plain, where back-barrier peatlands transformed into open tidal basins. Presence of compaction-prone peat and intensified artificial drainage led to subsidence. This precondition and slow anthropogenic forcing combined, made the area more sensitive to stochastically occurring storms, which could serve as tipping points for large-scale drowning. Eventually, major peatlands turned into tidal areas that for many centuries would remain unsuitable for habitation. Human-induced peatland subsidence also led to the formation of the new Hollandse IJssel and Lek river branches. This marked a major reorganisation of the river network in the lower Rhine–Meuse delta. In the middle and upstream parts of the delta, the landscape was more stable. Yet, settlements on the natural levees show adaption to increasing flooding frequency from the Late Roman period onwards. The settlements shifted towards higher positions, while route networks between them largely remained intact. Smaller-scale landscape changes were found in the Pleistocene sand area. Here, local sand drifting occurred, most frequently occurring close to human ...