Polymorphism in the promoter region of the insulin-like growth factor I gene is related to carotid intima-media thickness and aortic pulse wave velocity in subjects with hypertension.
BACKGROUND AND PURPOSE: Low circulating levels of insulin-like growth factor I (IGF-I) have been associated with an increased risk for atherosclerosis. Absence of the 192-bp (wild-type) allele in the promoter region of the IGF-I gene has been associated with low circulating IGF-I levels. We examined the role of this polymorphism in relation to blood pressure and 2 early markers of atherosclerosis: carotid intima-media thickness (IMT) and aortic pulse wave velocity (PWV). METHODS: A total of 5132 subjects of the Rotterdam Study, aged 55 to 75 years, were included in this study. In 3769 subjects... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2003 |
Schlagwörter: | *Polymorphism / Genetic / *Promoter Regions (Genetics) / Aged / Aorta/*physiopathology / Arteriosclerosis/epidemiology/genetics / Blood Pressure/genetics / Carotid Arteries/*physiopathology / Comorbidity / Female / Gene Frequency / Humans / Hypertension/epidemiology/genetics/*physiopathology / Insulin-Like Growth Factor I/*genetics / Male / Middle Aged / Netherlands/epidemiology / Prevalence / Pulsatile Flow/genetics / Risk Assessment / Risk Factors / Tunica Intima / Tunica Media |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28785973 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/13164 |