Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study
Studies of the roles of variants of the IGF-I gene in the regulation of bone mineral density (BMD) have yielded conflicting results. We examined the role of a microsatellite repeat polymorphism in one of the promoter regions of the IGF-I gene in relation to femoral BMD in elderly women and men from the Rotterdam Study. We studied 5648 and 4134 individuals at baseline and follow-up ( approximately 2 yr later), respectively. Femoral BMD measurements were performed using dual energy x-ray absorptiometry. In women, baseline BMD levels were, on the average, 0.02 g/cm(2) [95% confidence interval (CI... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2003 |
Schlagwörter: | Aged/*physiology / Alleles / Birth Weight/genetics / Bone Density/*genetics / Cohort Studies / Diabetes Mellitus / Type 2/genetics / Female / Gene Frequency / Genotype / Humans / Insulin-Like Growth Factor I/*genetics / Male / Middle aged / Netherlands / Polymorphism / Genetic/*genetics / Promoter Regions (Genetics)/*genetics / Research Support / Non-U.S. Gov't |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28785530 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/10204 |