Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study) Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands
BACKGROUND: Observational studies suggest a synergistic effect of hypertension and hyperlipidaemia on the progression of atherosclerosis. The alpha-blocker doxazosin has favourable effects on plasma lipids, insulin resistance and blood pressure, while the diuretic hydrochlorothiazide (HCTZ) principally affects blood pressure and increases insulin resistance. METHODS: A randomised double-blind study over 36 months was performed to compare the effects of doxazosin and HCT
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2002 |
Schlagwörter: | Aged / Antihypertensive Agents/*pharmacology / Arteriosclerosis/*pathology / Carotid Arteries/drug effects / Disease Progression / Diuretics / Double-Blind Method / Doxazosin/*pharmacology / Femoral Artery/drug effects / Humans / Hydrochlorothiazide/*pharmacology / Hypercholesterolemia/*complications / Hypertension/*complications / Male / Middle aged / Research Support / Non-U.S. Gov't / Sodium Chloride Symporter Inhibitors/*pharmacology |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28785502 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/10092 |