Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h 2 total ), and the propo... Mehr ...
Verfasser: |
Hagenbeek, Fiona A.
Pool, Rene
van Dongen, Jenny
Draisma, Harmen H. M.
Jan Hottenga, Jouke
Willemsen, Gonneke
Abdellaoui, Abdel
Fedko, Iryna O.
den Braber, Anouk
Visser, Pieter Jelle
de Geus, Eco J. C. N.
Willems van Dijk, Ko
Verhoeven, Aswin
Suchiman, H. Eka
Beekman, Marian
Slagboom, P. Eline
van Duijn, Cornelia M.
Harms, Amy C.
Hankemeier, Thomas
Bartels, Meike
Nivard, Michel G.
Boomsma, Dorret I. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
BBMRI Metabolomics Consortium , Hagenbeek , F A , Pool , R , van Dongen , J , Draisma , H H M , Jan Hottenga , J , Willemsen , G , Abdellaoui , A , Fedko , I O , den Braber , A , Visser , P J , de Geus , E J C N , Willems van Dijk , K , Verhoeven , A , Suchiman , H E , Beekman , M , Slagboom , P E , van Duijn , C M , Harms , A C , Hankemeier , T , Bartels , M , Nivard , M G & Boomsma , D I 2020 , ' Heritability estimates for 361 blood metabolites across 40 genome-wide association studies ' , Nature Communications , vol. 11 , no. 1 , 39 . https://doi.org/10.1038/s41467-019-13770-6 |
Schlagwörter: |
NETHERLANDS TWIN REGISTER
/ MISSING HERITABILITY
/ GENOTYPE IMPUTATION
/ VARIANCE-ESTIMATION
/ METABOLOMICS
/ SELECTION
/ DATABASE
/ BIOBANK |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28779683 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://hdl.handle.net/11370/af59d13e-7f0d-4b38-bfb4-d53e1d47e711 |