Ten-year recurrence rates for breast cancer subtypes in the Netherlands:A large population-based study
Here we report for the first time the relation between breast cancer subtypes and 10-year recurrence rates and mortality in the Netherlands. All operated women diagnosed with invasive non-metastatic breast cancer in 2005 in the Netherlands were included. Patients were classified into breast cancer subtypes according to ER, PR, HER2 status and grade: luminal A, luminal B, HER2 positive and triple negative. Percentages and hazards of recurrence were compared among subtypes. Adjusted 10-year overall (OS) and recurrence-free survival (RFS) were calculated using multivariable Cox regression. Of 8,0... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2019 |
Reihe/Periodikum: | van Maaren , M C , de Munck , L , Strobbe , L J A , Sonke , G S , Westenend , P J , Smidt , M L , Poortmans , P M P & Siesling , S 2019 , ' Ten-year recurrence rates for breast cancer subtypes in the Netherlands : A large population-based study ' , International Journal of Cancer , vol. 144 , no. 2 , pp. 263-272 . https://doi.org/10.1002/ijc.31914 |
Schlagwörter: | breast cancer subtypes / breast cancer / recurrence / 10-year follow-up / population-based / hazard / MOLECULAR SUBTYPES / REGIONAL RECURRENCE / HISTOLOGICAL GRADE / ENDOCRINE THERAPY / EXPRESSION / RECEPTOR / IMPACT / RECOMMENDATIONS / CLASSIFICATION / PATTERNS |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28779408 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://hdl.handle.net/11370/93030321-5a64-4461-bc38-8c832aa9a148 |
Here we report for the first time the relation between breast cancer subtypes and 10-year recurrence rates and mortality in the Netherlands. All operated women diagnosed with invasive non-metastatic breast cancer in 2005 in the Netherlands were included. Patients were classified into breast cancer subtypes according to ER, PR, HER2 status and grade: luminal A, luminal B, HER2 positive and triple negative. Percentages and hazards of recurrence were compared among subtypes. Adjusted 10-year overall (OS) and recurrence-free survival (RFS) were calculated using multivariable Cox regression. Of 8,062 patients, 4,482 (56%) were luminal A, 2,090 (26%) luminal B, 504 (6%) HER2 positive and 986 (12%) triple negative. Local recurrences (7.5%) and distant metastases (25.6%) occurred most often in HER2 positive disease and the least often in luminal A (3.7% and 9.5%, respectively). Regional recurrences were most often diagnosed in triple negative disease (5.2%), and the least often in luminal A (1.7%). HER2 positive and triple negative subtypes had the highest recurrence rates in the second year, while luminal A and B showed a more continuous pattern over time, with lobular tumours recurring more often. After adjustment for differences in baseline characteristics, triple negative disease showed worse 10-year OS and triple negative and HER2 positive disease had the lowest 10-year RFS. In the Netherlands, breast cancer subtypes are important predictors for 10-year recurrence rates. Knowledge on recurrence and survival rates according to these different subtypes, in combination with other prognostic factors, can support patient-tailored treatment and individualised follow-up.