Background-C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. Methods and Results-We performed a genome-wide association analysis of CRP in 66 185 participants from 15 population-based studies. We sought replication for the genome-wide significant and suggestive loci in a replication panel comprising 16 540 individuals from 10 independent studies. We found 18 genome-wide significant loci, and we provided evidence of replication for 8 of them.... Mehr ...
| Verfasser: |
Dehghan, Abbas
Dupuis, Josee
Barbalic, Maja
Bis, Joshua C.
Eiriksdottir, Gudny
Lu, Chen
Pellikka, Niina
Wallaschofski, Henri
Kettunen, Johannes
Henneman, Peter
Baumert, Jens
Strachan, David P.
Fuchsberger, Christian
Vitart, Veronique
Wilson, James F.
Pare, Guillaume
Naitza, Silvia
Rudock, Megan E.
Surakka, Ida
de Geus, Eco J. C.
Alizadeh, Behrooz Z.
Guralnik, Jack
Shuldiner, Alan
Tanaka, Toshiko
Zee, Robert Y. L.
Schnabel, Renate B.
Nambi, Vijay
Kavousi, Maryam
Ripatti, Samuli
Nauck, Matthias
Smith, Nicholas L.
Smith, Albert V.
Sundvall, Jouko
Scheet, Paul
Liu, Yongmei
Ruokonen, Aimo
Rose, Lynda M.
Larson, Martin G.
Hoogeveen, Ron C.
Freimer, Nelson B.
Teumer, Alexander
Tracy, Russell P.
Launer, Lenore J.
Buring, Julie E.
Yamamoto, Jennifer F.
Folsom, Aaron R.
Sijbrands, Eric J. G.
Pankow, James
Elliott, Paul
Keaney, John F.
Sun, Wei
Sarin, Antti-Pekka
Fontes, Joao D.
Badola, Sunita
Astor, Brad C.
Hofman, Albert
Pouta, Anneli
Werdan, Karl
Greiser, Karin H.
Kuss, Oliver
Schwabedissen, Henriette E. Meyer Zu
Thiery, Joachim
Jamshidi, Yalda
Nolte, Ilja M.
Soranzo, Nicole
Spector, Timothy D.
Voelzke, Henry
Parker, Alexander N.
Aspelund, Thor
Bates, David
Young, Lauren
Tsui, Kim
Siscovick, David S.
Guo, Xiuqing
Rotter, Jerome I.
Uda, Manuela
Schlessinger, David
Rudan, Igor
Hicks, Andrew A.
Penninx, Brenda W.
Thorand, Barbara
Gieger, Christian
Coresh, Joe
Willemsen, Gonneke
Harris, Tamara B.
Uitterlinden, Andre G.
Jaervelin, Marjo-Riitta
Rice, Kenneth
Radke, Doerte
Salomaa, Veikko
van Dijk, Ko Willems
Boerwinkle, Eric
Vasan, Ramachandran S.
Ferrucci, Luigi
Gibson, Quince D.
Bandinelli, Stefania
Snieder, Harold
Boomsma, Dorret I.
Xiao, Xiangjun
Campbell, Harry
Hayward, Caroline
Pramstaller, Peter P.
van Duijn, Cornelia M.
Peltonen, Leena
Psaty, Bruce M.
Gudnason, Vilmundur
Ridker, Paul M.
Homuth, Georg
Koenig, Wolfgang
Ballantyne, Christie M.
Witteman, Jacqueline C. M.
Benjamin, Emelia J.
Perola, Markus
Chasman, Daniel I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2011 |
| Reihe/Periodikum: |
Dehghan , A , Dupuis , J , Barbalic , M , Bis , J C , Eiriksdottir , G , Lu , C , Pellikka , N , Wallaschofski , H , Kettunen , J , Henneman , P , Baumert , J , Strachan , D P , Fuchsberger , C , Vitart , V , Wilson , J F , Pare , G , Naitza , S , Rudock , M E , Surakka , I , de Geus , E J C , Alizadeh , B Z , Guralnik , J , Shuldiner , A , Tanaka , T , Zee , R Y L , Schnabel , R B , Nambi , V , Kavousi , M , Ripatti , S , Nauck , M , Smith , N L , Smith , A V , Sundvall , J , Scheet , P , Liu , Y , Ruokonen , A , Rose , L M , Larson , M G , Hoogeveen , R C , Freimer , N B , Teumer , A , Tracy , R P , Launer , L J , Buring , J E , Yamamoto , J F , Folsom , A R , Sijbrands , E J G , Pankow , J , Elliott , P , Keaney , J F , Sun , W , Sarin , A-P , Fontes , J D , Badola , S , Astor , B C , Hofman , A , Pouta , A , Werdan , K , Greiser , K H , Kuss , O , Schwabedissen , H E M Z , Thiery , J , Jamshidi , Y , Nolte , I M , Soranzo , N , Spector , T D , Voelzke , H , Parker , A N , Aspelund , T , Bates , D , Young , L , Tsui , K , Siscovick , D S , Guo , X , Rotter , J I , Uda , M , Schlessinger , D , Rudan , I , Hicks , A A , Penninx , B W , Thorand , B , Gieger , C , Coresh , J , Willemsen , G , Harris , T B , Uitterlinden , A G , Jaervelin , M-R , Rice , K , Radke , D , Salomaa , V , van Dijk , K W , Boerwinkle , E , Vasan , R S , Ferrucci , L , Gibson , Q D , Bandinelli , S , Snieder , H , Boomsma , D I , Xiao , X , Campbell , H , Hayward , C , Pramstaller , P P , van Duijn , C M , Peltonen , L , Psaty , B M , Gudnason , V , Ridker , P M , Homuth , G , Koenig , W , Ballantyne , C M , Witteman , J C M , Benjamin , E J , Perola , M & Chasman , D I 2011 , ' Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels ' , Circulation , vol. 123 , no. 7 , pp. 731-738 . https://doi.org/10.1161/CIRCULATIONAHA.110.948570 |
| Schlagwörter: |
genetics
/ inflammation
/ meta-analysis
/ myocardial infarction
/ genome-wide association study
/ CORONARY-HEART-DISEASE
/ GENETICALLY ISOLATED POPULATION
/ NETHERLANDS TWIN REGISTER
/ EPIDEMIOLOGIC APPLICATIONS
/ COMMON VARIANTS
/ ALPHA-GENE
/ CRP GENE
/ DESIGN
/ FRAMINGHAM |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-28778136 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://hdl.handle.net/11370/1f16c9fe-a15e-4bae-91fe-ecea2e3dd6dc |
