BACKGROUND: Because the number of elderly von Willebrand disease (VWD) patients is increasing, the pathophysiology of aging in VWD has become increasingly relevant. OBJECTIVES: To assess age-related changes in von Willebrand factor (VWF) and factor VIII (FVIII) levels and to compare age-related differences in bleeding phenotype between elderly VWD patients and those <65 years. We also studied co-morbidity in elderly patients. PATIENTS/METHODS: We included VWD patients with VWF levels ≤ 30 U dL(-1) in the nationwide cross-sectional 'Willebrand in the Netherlands' (WiN-) study. Patients repor... Mehr ...
Verfasser: |
Sanders, YV
Giezenaar, M A
Laros-van Gorkom, BAP
Meijer, K
van der Bom, JG
Cnossen, MH
Nijziel, MR
Ypma, PF
Fijnvandraat, K
Eikenboom, J
Mauser-Bunschoten, EP
Leebeek, FWG |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2014 |
Reihe/Periodikum: |
Sanders , YV , Giezenaar , M A , Laros-van Gorkom , BAP , Meijer , K , van der Bom , JG , Cnossen , MH , Nijziel , MR , Ypma , PF , Fijnvandraat , K , Eikenboom , J , Mauser-Bunschoten , EP & Leebeek , FWG 2014 , ' von Willebrand disease and aging: an evolving phenotype. ' , Journal of Thrombosis and Haemostasis , vol. 12 , no. 7 , pp. 1066-75 . https://doi.org/10.1111/jth.12586 |
Schlagwörter: |
80 and over
/ Adolescent
/ Adult
/ Age Factors
/ Aged
/ Aging
/ Cross-Sectional Studies
/ Female
/ Hemorrhage
/ Hospitalization
/ Humans
/ Male
/ Middle Aged
/ Netherlands
/ Phenotype
/ Young Adult
/ von Willebrand Diseases
/ von Willebrand Diseases: physiopathology
/ von Willebrand Diseases: therapy
/ von Willebrand Factor
/ von Willebrand Factor: metabolism |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-28775311 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://cris.maastrichtuniversity.nl/en/publications/c4334a9c-259b-45a2-9a22-6ef11d69f0e0 |