The evolution of subtype B HIV-1 tat in the Netherlands during 1985-2012
For the production of viral genomic RNA, HIV-1 is dependent on an early viral protein, Tat, which is required for high-level transcription. The quantity of viral RNA detectable in blood of HIV-1 infected individuals varies dramatically, and a factor involved could be the efficiency of Tat protein variants to stimulate RNA transcription. HIV-1 virulence, measured by set-point viral load, has been observed to increase over time in the Netherlands and elsewhere. Investigation of tat gene evolution in clinical isolates could discover a role of Tat in this changing virulence. A dataset of 291 Dutch... Mehr ...
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Dokumenttyp: | Journal article |
Erscheinungsdatum: | 2018 |
Verlag/Hrsg.: |
Elsevier
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Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-28774059 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.1016/j.virusres.2018.04.008 |