Modulation of Contact System Proteases by Glycosaminoglycans SELECTIVE ENHANCEMENT OF THE INHIBITION OF FACTOR XIa

Abstract We investigated the influence of dextran sulfate, heparin, heparan sulfate, and dermatan sulfate on the inhibition of FXIa (where FXIa is activated factor XI, for example), FXIIa, and kallikrein by C1 inhibitor, α1-antitrypsin, α2-antiplasmin, and antithrombin III. The second-order rate constants for the inhibition of FXIa by C1 inhibitor, α1-antitrypsin, α2-antiplasmin, and antithrombin III, in the absence of glycosaminoglycans, were 1.8, 0.1, 0.43, and 0.32 × 103 M−1 s−1, respectively. The rate constants of the inactivation of FXIa by C1 inhibitor and by antithrombin III increased u... Mehr ...