Table_1_Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands.xlsx

Objectives Certain Group B Streptococcus (GBS) genotypes are associated with invasive disease in neonates. We conducted a comparative genomic analysis of GBS isolates from neonatal disease and maternal carriage in the Netherlands to determine distribution of genetic markers between the two host groups. Methods Whole genome sequencing was used to characterise 685 neonatal invasive isolates (2006–2021) and 733 maternal carriage isolates (2017–2021) collected in the Netherlands. Results Clonal complex (CC) 17 and serotype III were significantly more common in disease while carriage isolates were... Mehr ...